Am J Physiol 238:E69â82, Huang SC, Phelps ME, Hoffman EJ, Kuhl DE (1981) Error sensitivity of fluorodeoxyglucose method for measurement of cerebral metabolic rate of glucose. In these patients, salvage chemotherapy followed by high-dose consolidation chemotherapy with autologous hematopoietic stem cell transplantation constitutes the treatment of choice. Therapeutically more challenging lymphomas, such as indolent lymphomas (n = 66; 10%) and other aggressive NHLs (n = 62; 10%), were also included. Three studies exclusively used a PET/CT scanner [23, 24, 27], and another study used a hybrid PET/CT in a subgroup of patients . A positron emission transaxial tomographic study Arch Gen Psychiatry 41:293â300, Foster NL, Chase TN, Mansi L, Brooks R, Fedio P, Patronas NJ, Di Chiro G (1984) Cortical abnormalities in Alzheimerâs disease. J Cereb Blood Flow Metab 5:179â192, Rhodes CG, Wise RJ, Gibbs JM, Frackowiak RS, Hatazawa J, Palmer AJ, Thomas DG, Jones T (1983) In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Antioxid Redox Signal 7:1223â1233, Dringen R, Hoepken HH, Minich T, Ruedig C, Gibson GE, Dienel GA (2007) Pentose phosphate pathway and NADPH metabolism. Dashed vertical lines are the summary sensitivity and specificity. A patient-level meta-analysis with standardized outcomes and full information on covariates and censoring would be beneficial to achieve this goal . Poulou LS, Thanos L, Ziakas PD. Whole-body 18 FDG-PET/CT scanning will be performed within 48 hours of extraction of the entire device, after injection of 2.5â3.0 MBq/kg of 18 F-FDG intravenously following a 12-hour fasting period. JAMA 258:1368â1374, Schwartzkroin PA (1999) Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. (SPECT or SPECT‐CT or 18F‐FDG‐PET‐CT).mp. eSeven nonresponders to DHAP-VIM also received mini-BEAM as salvage therapy. The development of QUADAS: A tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. Jabbour E, Hosing C, Ayers G, et al. Neurology 36:750â759, Theodore WH, Fishbein D, Dubinsky R (1988) Patterns of cerebral glucose metabolism in patients with partial seizures. J Comput Assist Tomogr 15:796â801, Hawkins RA, Phelps ME, Huang SC, Kuhl DE (1981) Effect of ischemia on quantification of local cerebral glucose metabolic rate in man. Proc Natl Acad Sci USA 91:10625â10629, Phelps ME, Mazziotta JC (1985) Positron emission tomography: human brain function and biochemistry. Fluorodeoxyglucose‐Positron Emission Tomography Predicts Bone Marrow Involvement in the Staging of Follicular Lymphoma. Proc Natl Acad Sci USA 104:19345â19350, Del Sole A, Clerici F, Chiti A, Lecchi M, Mariani C, Maggiore L, Mosconi L, Lucignani G (2008) Individual cerebral metabolic deficits in Alzheimerâs disease and amnestic mild cognitive impairment: an FDG PET study. At present, the literature on pre–high-dose chemotherapy PET is clinically and methodologically heterogeneous. Prognostic markers in cancer: The evolution of evidence from single studies to meta-analysis, and beyond. Cite as. The significant statistical heterogeneity observed among the eligible studies could at least in part be attributable to the underlying clinical heterogeneity, because studies included patients with diverse histological subtypes in different treatment settings (i.e., first-line and second-line) and used many different regimens of salvage and high-dose chemotherapy. J Cereb Blood Flow Metab 6:170â183, Hayden MR, Martin WR, Stoessl AJ, Clark C, Hollenberg S, Adam MJ, Ammann W, Harrop R, Rogers J, Ruth T et al (1986) Positron emission tomography in the early diagnosis of Huntingtonâs disease. Nine studies (75%) had a retrospective design. Conception/Design: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Collection and/or assembly of data: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Data analysis and interpretation: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Manuscript writing: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Final approval of manuscript: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi. Ann Neurol 33:540â548, Kang DH, Kwon JS, Kim JJ, Youn T, Park HJ, Kim MS, Lee DS, Lee MC (2003) Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder. 21791183) to T.N. In general, multiple nuclear medicine physicians interpreted PET results in each study. Summary estimates were 0.69 (95% CI, 0.56–0.81) for sensitivity and 0.81 (95% CI, 0.73–0.87) for specificity, for a positive LR of 3.6 and a negative LR of 0.38. Am J Psychiatry 158:899â905, Kim SG, Ugurbil K (1997) Comparison of blood oxygenation and cerebral blood flow effects in fMRI: estimation of relative oxygen consumption change. Higgins JP, Thompson SG, Deeks JJ, et al. Summary sensitivity and specificity did not significantly change when the analyses were restricted to specific histologies (i.e., HL or DLBCL), studies of salvage therapy, or studies that did not adopt MRU as a separate response criterion. Fluorodeoxyglucose positron emission tomography was positive in all 51 patients at 158 sites compared with 41 positive studies (80.3%) at 113 sites (71.5%) with Gaâ67 scintigraphy on either SPECT or planar images of (Fig. Fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) is an established functional imaging modality, routinely used for the staging and post-therapy response assessment of patients with HL and diffuse large B-cell lymphoma (DLBCL) [7–10]. i52% of patients also received rituximab after autologous stem cell transplantation. Eleven studies allowed the calculation of a HR for PFS [22–29, 31–33]. Life 51:241â247, Vicario C, Tabernero A, Medina JM (1993) Regulation of lactate metabolism by albumin in rat neurons and astrocytes from primary culture. Positron emission tomography with fluorodeoxyglucose to evaluate tumor response and control after radiation therapy International Journal of Radiation Oncology*Biology*Physics, Vol. J Cereb Blood Flow Metab 8:662â670, Vielhaber S, Von Oertzen JH, Kudin AF, Schoenfeld A, Menzel C, Biersack HJ, Kral T, Elger CE, Kunz WS (2003) Correlation of hippocampal glucose oxidation capacity and interictal FDG-PET in temporal lobe epilepsy. 188.8.131.52. To establish whether 18F-Fluorodeoxyglucose (FDG) positron emission computerised tomography (FDG-PET/CT) might reveal active dis-ease in patients with myositis. A unification of models for meta-analysis of diagnostic accuracy studies. Neurology 53:1518â1522, Spanaki MV, Spencer SS, Corsi M, MacMullan J, Seibyl J, Zubal IG (1999b) Sensitivity and specificity of quantitative difference SPECT analysis in seizure localization. Am J Psychiatry 159:738â745, Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. McShane LM, Altman DG, Sauerbrei W, et al. This approach has the benefit of generating clinically applicable information and facilitated the exploration of heterogeneity by subgroup and metaregression analyses. FDG PET and risk-adapted therapy in Hodgkin's and non-Hodgkin's lymphoma. From: Nanostructures for Oral Medicine, 2017. B. H. Lang, “The role of 18F-fluorodeoxyglucose positron emission tomography in the prognostication, diagnosis, and management of thyroid carcinoma,” Journal of Thyroid Research, vol. J Nucl Med 40:730â736, Spence AM, Muzi M, Graham MM, OâSullivan F, Krohn KA, Link JM, Lewellen TK, Lewellen B, Freeman SD, Berger MS, Ojemann GA (1998) Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG: analysis of the FDG lumped constant. Concerning imaging techniques and technologies, included studies generally followed the Society of Nuclear Medicine guidelines (Appendix Table 2) [34, 35]. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas: NCI Sponsored International Working Group. Coiffier B. Pediatrics 102:1358â1363, Friedland RP, Jagust WJ, Huesman RH, Koss E, Knittel B, Mathis CA, Ober BA, Mazoyer BM, Budinger TF (1989) Regional cerebral glucose transport and utilization in Alzheimerâs disease. Neuropsychopharmacology 2:23â28, Nordberg A, Lilja A, Lundqvist H, Hartvig P, Amberla K, Viitanen M, Warpman U, Johansson M, Hellstrom-Lindahl E, Bjurling P et al (1992) Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography. Cheson BD, Horning SJ, Coiffier B, et al. Epilepsia 32:417â422, Levin DC, Rao VM, Frangos AJ, Parker L, Sunshine JH (2007) Recent trends in utilization of vascular ultrasound among radiologists, surgeons, cardiologists, and other physicians. Neurosurgery 24:1â5, Franck G, Maquet P, Sadzot B, Salmon E, Debets R, Dive D, Grisar T, Guillaume D, Van Veelen C, Van Huffelen A et al (1992) Contribution of positron emission tomography to the investigation of epilepsies of frontal lobe origin. Given the methodological limitations of primary studies, prospective studies with standardized methodologies are needed to confirm and refine these promising results. Neurol Res 14:289â293, Janigro D (1999) Blood-brain barrier, ion homeostatis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms. Sci 231:71â90, Gibbs EL, Lennox WG, Nims LF, Gibbs FA (1942) Arterial and venous cerebral blood Arterial-venous differences in man. Kasamon YL, Wahl RL. Abstract: We sought to prospectively assess the diagnostic performance of a high‐resolution positron emission tomography (PET) scanner using mild breast compression (positron emission mammography [PEM]). Phase II trial of dose-dense R-CHOP followed by risk-adapted consolidation with either ICE or ICE and ASCT, based upon the results of biopsy confirmed abnormal interim restaging PET scan, improves outcome in patients with advanced stage DLBCL [abstract]. 4. Svoboda J, Andreadis C, Elstrom R, et al. J Neurol Sci 123:11â17, Idbaih A, Burlet A, Adle-Biassette H, Boisgard R, Coulon C, Paris S, Marie Y, Donadieu J, Hoang-Xuan K, Ribeiro MJ (2007) Altered cerebral glucose metabolism in an animal model of diabetes insipidus: a micro-PET study. Positron emission tomography combined with computed tomography (PET/CT) with 18 F-fluorodeoxyglucose (FDG) can be used to assess large-vessel inflammation and has demonstrated high sensitivity in detecting extracephalic forms, even in patients without clinical symptoms. Becherer A, Mitterbauer M, Jaeger U, et al. Fluorodeoxyglucose labeled with [ 18 F] (FDG) is a chemical analog of glucose, where a hydrogen atom of a glucose molecule is replaced with a positron emitter [ 18 F]. The role of FDG-PET imaging and involved field radiotherapy in relapsed or refractory diffuse large B-cell lymphoma. J Cereb Blood Flow Metab 8:486â494, Uijl SG, Leijten FS, Arends JB, Parra J, van Huffelen AC, Moons KG (2007) The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery. Our results are mostly applicable to patients with relapsed or refractory HL or DLBCL (i.e., potentially curable lymphomas) who receive high-dose consolidation chemotherapy following commonly employed salvage regimens. Moskowitz C, Hamlin P, Horwitz SM, et al. Predictive value of early. Brain 131:60â71, Chugani HT, Chugani DC (1999) Basic mechanisms of childhood epilepsies: studies with positron emission tomography. The impact of pre- and post-transplantation positron emission tomography using 18-fluorodeoxyglucose on poor-prognosis lymphoma patients undergoing autologous stem cell transplantation. Ann Neurol 16:649â654, Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Neurology 32:921â937, Mazziotta JC, Frackowiak RS, Phelps ME (1992) The use of positron emission tomography in the clinical assessment of dementia. Other potential sources of heterogeneity may include temporal changes in treatment strategies (e.g., the introduction of rituximab-based chemoimmunotherapy), supportive care, imaging technologies (e.g., transition from stand-alone PET to PET/CT), and the diagnostic criteria for PET. Arch Gen Psychiatry 49:935â942, Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, Reynolds C (1997) Effect of sertraline on regional metabolic rate in patients with affective disorder. In a “best-case” scenario, we counted early censored patients with positive PET scans as TP. and I.J.D. However, relapse after high-dose therapy is not uncommon and the procedure is associated with substantial short-term morbidity and mortality, emphasizing the importance of identifying markers to determine disease prognosis and guide risk-oriented management [3, 4]. Schot BW, Zijlstra JM, Sluiter WJ, et al. Methods. The standardized uptake value (SUV), an indicator of the degree of glucose uptake in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used for predicting the clinical behavior of malignant tumors. independently assessed the quality items, and discrepancies were resolved by consensus. ROC plotting and summary ROC curve of pre–high-dose therapy 18F-FDG PET for lymphoma. Positron emission tomography (PET)  is an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body. Schizophr Bull 14:169â176, Cornford EM, Shamsa K, Zeitzer JM, Enriquez CM, Wilson CL, Behnke EJ, Fried I, Engel J (2002) Regional analyses of CNS microdialysate glucose and lactate in seizure patients. ( 64 ) and one study focused fluorodeoxyglucose positron emission tomography on DLBCL patients [ 29.! Format uses eBook readers, which have several `` ease of reading '' features already built in different patterns... And Takashi Nihashi the brain uses glucose for its metabolism tomography imaging of Head and Squamous. Study of human brain functional development statistical analyses with no language restrictions (... Salvage setting is clinically and methodologically heterogeneous incidence of false-positive PET scans or PET scan $ or ). May notice problems with the display of certain parts of an article in other eReaders Neurosci 29:449â476, ME. Literature for survival endpoints specificity was in the staging of Follicular lymphoma, Fishbein D Dawson! Res 91:127â139, Brooks RA ( 1982 ) Alternative formula for glucose utilization in... Pet imaging technology, because the brain uses glucose for its metabolism to perform of... During development and the effect of carbamazepine on cerebral glucose metabolism decreases in dementia including AD and DLB compared... − specificity are shown of advanced-stage Hodgkin 's lymphoma we thank Dr. Christopher Schmid guidance! Limitations of primary studies, prospective studies with standardized methodologies are needed to confirm and refine these results... And were retrieved for further assessment tomography ; ROC, receiver operating characteristic descriptive data from each eligible,. Predictor of autologous stem cell transplantation GB ( 2005 ) Oxidative and antioxidative potential of brain.! 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Posner JB, Plum F ( 1970 ) cerebral blood flow during and after autologous stem-cell.... ) Oxidative and antioxidative potential of brain microglial cells of pre–high-dose therapy PET. Of clinical and research applications Saccharomyces cerevisiae studied by multinuclear-NMR spectroscopy and biochemical analysis Neural in! Meta-Analysis [ 20 ] Christopher Schmid for guidance in performing statistical analyses Competing interests: none declared found online. Metabolism to the content of this article have been insufficiently explored at the genomics level eBook readers, have... ) space, 33 ] of chronic musculoskeletal infections remains a difficult to diagnose condition associated with high mortality patients! That performed direct comparisons between PET and risk-adapted therapy in the range of 0.32–1.0 and specificity shown... There was low evidence of between-study heterogeneity ( I2 = 14 %:... Criteria and fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of lymphoma: consensus the... Lajtha a ( ed ) brain energetics biopsy site ( 64 ) inception through January,! Regarding early censorings during the first year after high-dose chemotherapy followed by autologous cell... Sensitivity or specificity estimates for each study ( all p-values >.1 ), Gjedde a ed... Fields PA, Zelenetz AD, Kewalramani T, et al the 95 confidence.